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Our study reveals that not all humans are equally predisposed to generate VRC01-class antibodies, not all predicted progenitor VRC01-expressing B cells can bind to Env, and the CDRH3 region of germline VRC01 antibodies influence their ability to recognize HIV-1.
Alternatively, and/or in addition, some may arise simply because specific regions of the genome are predisposed to generate piRNAs, with whatever is inserted into the locus becoming a substrate for piRNA production.
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This means that, while the HMM algorithm is predisposed to generating false-positive LOH calls as a result of consanguinity in individual patient's family trees and the subsequent enrichment of homozygosity, the cross-sectional approach adopted by the CHC algorithm is not as heavily affected by individual genetic background.
Due to their high lipid content, active metabolism, and the phagocytosis of photoreceptor outer segments (POS) that are composed of readily-oxidized poly-unsaturated fatty acids, RPE cells are naturally predisposed to oxidative stress generated by lipid peroxidation10,13.
The reaction has been suggested to proceed via the η-complex 102 (with pentacoordinated Pd), predisposed to the syn-cyclopalladation, generating the tetrahydrofuran intermediate 103.
I'm predisposed to want to give them my business.
"I came predisposed to like it," Father Kantzavelos said.
Rapidly accelerating flow and inspiratory flow (and the rates of change of pressure they generate (dP/dT)) cause major stress on dependent lung zones most predisposed to VILI.
Reducing RnrL function did not reduce compensatory growth as mutant cells were able to generate a normally sized posterior compartment; rather, mutant cells engaged in compensatory growth appeared to be predisposed to apoptosis.
Are we predisposed to diabetes?
I'm predisposed to it.
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