In the present study, every additional previously failed fistula increased the risk of initial failure and 3-month failure 4- and 6-fold, respectively, indicating that some patients may be predisposed to fistula failure, perhaps due to anatomical or thrombophylic factors, or to pre-existing venous intimal hyperplasia [ 3].
A potential mechanism by which critically ill patients may be predisposed to antithrombotic failure is the inability to achieve 'prophylactic' anticoagulant drug levels as a result of impaired absorption.
As a result, septic patients are predisposed to acute renal failure [ 44].
Patients with end-stage renal disease (ESRDPos) usually have multiple comorbidities and are predisposed to acute organ failure and in-hospital mortality.
The computed factor of safety of the slopes ranged from 1.00 to 1.30, implying critical stability which indicates liability of the slopes to failure when predisposed to landslide triggering agents.
Individuals who have cardiac hypertrophy and cardiomyopathies are predisposed to the development of heart failure (Vasan et al., 1997).
The PPARα-null mouse is particularly predisposed to alcohol-induced hepatotoxicity, as a failure to express PPARα reduces the conversion of tryptophan to NAD+ (nicotine adenine dinucleotide+), which exacerbates the action of alcohol and its reducing potential on the liver.
In fact, individuals who receive certain chemotherapy antagonists directed towards RTKs are predisposed to developing dilated cardiomyopathy and heart failure (Chen et al., 2008; Chu et al., 2007; Suter et al., 2007).
The critically ill patient is especially predisposed to thromboembolism, possessing many inherent risk factors: cardiac failure, trauma, sepsis, cancer, increasing age, and obesity [ 1- 5].
For example, K8 R341H was significantly overrepresented in US patients with end-stage liver disease versus the control subjects [ 19] and in patients with acute liver failure, the presence of K8 R341H predisposed to adverse disease outcome [ 6].
