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The accident investigation approach is rooted in psychology and engineering, and the investigation framework supports a classificatory approach that highlights how processes and the organisation and management of work can predispose to errors and mistakes among human players in the system.
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The characteristics of each of these stages may prevent or predispose to potential errors, which may lead to patient harm.
It could be postulated that even though the hormonal environment in the ovaries of these patients could predispose to meiotic errors, the high rates of mosaicism characteristic of preimplantation embryos could disguise the oocyte chromosomal status.
The recurrence risk for another child with UPD is generally low with the exception of those UPDs affecting acrocentric chromosomes (chromosomes 14 and 15): these chromosomes are prone to Robertsonian translocations (RT) which predispose to non-disjunctional errors and thus a UPD formation.
Previous studies suggest that burnout, particularly emotional exhaustion, is common among physicians [ 2– 7], affects morale and productivity, but also reduces quality of care and predisposes to medical errors [ 8– 11].
Chronic inflammation induces increased tissue turnover, which is thought to predispose to an excessive rate of proliferation, and in many cases results in more frequent mitotic errors and an increased rate of mutagenesis.
Plausible and non-exclusive explanations could be that CTLP might frequently arise due to previously established errors in the maintenance of genomic stability, or that chromothriptic aberrations involving genomic maintenance genes may predispose to the acquisition of additional CNA.
DNA repair defects directly predispose to malignancy.
Moderate kidney disease may predispose to infection.
A nonreducing hernia may predispose to failure of ARS.
Furthermore, asthmatics have lifestyle issues that may predispose to GER.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com