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We performed the same test on the set of 20 rSNPs for which the affected TF is known provided by Andersen et al. as Dataset S2 [ 5]. rSNP-MAPPER predicts score changes above the suggested threshold of 2 for 18 of them (90%), while if the threshold is lowered to 1.5 the number increases to 19 out of 20 (95%).
We tested rSNP-MAPPER on a list of 11 known disease-associated regulatory SNPs provided by Macintyre et al. as part of the description of their is-rSNP system (see Table 2 in [ 6]). rSNP-MAPPER predicts score changes above the suggested threshold of 2 for 10 out of 11 rSNPS (90%).
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However, the geometric distance scoring system predicts scores based on only local structure embedded by the data, thus leaving much room for improvement in terms of prediction accuracy.
Amongst the top predictions for COX is a known antiinflammatory drug Cicloprofen (D03489), so the high predicted score is encouraging.
It was the predicted score that baffled him.
What's your predicted score for Super Bowl XLVII?
They bet that the total final score of a game will be either over or under a predicted score.
The calculation for Ms. Isaacson's 3.69 predicted score is even more daunting.
In six patients, the reported score was in fact higher than the predicted score, and all but three fell within one standard deviation of the predicted score.
If the predicted score of the target network is greater than the predicted score of the current network and the acceptable threshold, a handover is initiated.
Figure 3 Correlation between the predicted score of NR-PWN and DMOS using the LIVE database.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com