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FFA are elevated in obese patients and are strong predictors of hepatic fat deposition (4).
Despite these limitations, the data presented here provide important initial insight into clinically-relevant predictors of hepatic steatosis in overweight and obese youth.
To identify independent predictors of hepatic fat content at baseline and of long-term reduction in hepatic fat after the dietary intervention, we conducted multivariate linear regression analyses.
Although conventional liver function tests are poor predictors of hepatic drug metabolism, there was a moderate correlation between plasma transaminase levels and measures of exogenous melatonin exposure.
However, only a preoperative platelet count of <150 × 10/μL, major hepatectomy, two-stage hepatectomy, and intraoperative red blood cell transfusion were independent <span class="lh">predictors of hepatic morbidity at multivariate analysis in the total study population.
Preclinical testing of future LNA ASO will need to include predictors of hepatic toxicity such as hepatic microsome or animal models (Hengstler et al, 2000; Swayze et al, 2007; Moeller et al, 2012).
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In one recent epidemiological study of several hundred patients with hepatitis C infection, daily cannabis use was found to be a predictor of hepatic steatosis (by microscopy) (11).
The gene identified as the best predictor of hepatic steatosis by the regression analysis, butyrylcholinesterase (BCHE) has been mostly studied in the context of its effect on the brain's cholinergic system [52].
Even more, it appears that waist circumference could also serve as a viable predictor of hepatic ATP production.
Measurement of liver stiffness using transient elastography is a noninvasive, reliable predictor of hepatic fibrosis, but data on its use in HIV infected patients are limited.
The low number of patients with diagnosed diabetes could also influence our results, as many studies have found that DMt2 is a major predictor of hepatic fibrosis [ 12].
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