Indeed, some health-predictor associations with age in participants were 'paradoxical,' consistent with greater apparent health in older age for study participants.
In addition, different predictor-outcome associations and additional predictors, that are not included in the model but are either more or less frequent in the new population, could play a role.
To describe experience from a behavioural medicine intervention among poorly controlled adult type 1 diabetes patients, in terms of feasibility, predictors and associations of improved glycaemic control.
To reduce the number of predictors, the associations between single risk factors and diagnostic groups were examined in preliminary analyses (see Table 1 for information about the included predictors).
But other predictors or associations of trainees' chronic disease exposure, and ways in which trainees consultations involving chronic disease differ from other consultations, have not been explored either in contemporary or in older studies.
To address this, we prospectively studied all older people admitted to six hospitals, investigating differences in dementia prevalence between hospital types, acute and elective admissions, and admitting specialities; and identifying predictors and associations of dementia.
Although we attempted to limit multiple comparisons by prioritizing seven 'primary predictors' where associations were expected, and relegating other factors to secondary status, longitudinal studies are needed to replicate our findings.
Whereas alcohol consumption certainly remains the single most prominent γ-GT predictor, significant associations with additional modifiable factors such as body mass index (BMI), coffee consumption and smoking have been shown repeatedly [1], [2], [8], [9], [10], [11], [12].
Finally, our simulation study only evaluated the performance of estimated multivariable predictor-outcome associations.
Diagnostic and prognostic literature is overwhelmed with studies reporting univariable predictor-outcome associations.
