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As such, vaccine clinical trial programs can be improved (1) by investigating baseline predictors (e.g., readouts from laboratory assays) of vaccine-induced immune responses, and (2) by implementing the proposed semiparametric efficient method in trials where baseline predictors are available.
Our predictors are available as a free web-based tool accessible at http://cbrc.kaust.edu.sa/dps.sa/dps
All three predictors are available for animal, fungal and plant proteins.
Further details on the training and accuracy of the various PONDR® predictors are available on the PONDR® web site.
Some additional PONDR® predictors are available at DisProt [ 15], but these have not been used in this study.
Only two related predictors are available: α-MoRF-PredII (Cheng et al., 2007) that supersedes α-MoRF-PredI (Oldfield et al., 2005) and ANCHOR (Dosztányi et al., 2009; Mészáros et al., 2009).
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For those samples in the longitudinal within-host data set where predictors were available for all four of the Human Leukocyte Antigen A (HLA-A) and HLA-B alleles of the host, the epitope cover ranged from 12% to 74%.
In December 2007, we performed an exhaustive search on the HIV Sequence Database (http://hiv.lanl.gov) for longitudinal within-host sequences from 4 digit HLA-genotyped patients that had not received antiretroviral therapy, and for which at least 3 matching MHC predictors were available.
Soft data were estimated only when all predictors were available.
*Not all information about outcome predictors was available from all patients.
Complete data on all risk predictors were available for all women, while complete data on alcohol consumption were available for 39.4% of men (n=417 560).
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