From here on, the term latent variables will be used for these combinations of predictors applied to PLSR, while the term principal components will be used for PCR.
The identification of tumor response predictors applying to a variety of radiotherapy and chemotherapy regimens will allow oncologists to customize strategies aimed at minimizing exposure to high-dose adjuvant therapy.
The C-statistic for the model of 2012 outcomes developed using 2011 predictors and the C-statistic based on the parameters from the model of 2011 outcomes regressed on 2010 predictors applied to the 2011 predictors and 2012 outcomes were very similar (0.856 and 0.853, respectively).
In Table 1, IBS mQTL refers to the IBS m predictor applied to the data set containing the causal variants.
To investigate this further, a secondary structure predictor coupled with a series of disorder predictors via a meta-predictor was applied to the 854 amino acid residues of full length human DISC1 (L-isoform, SwissProt Accession Number: Q9NRI5).
Several different cell line-derived drug response predictors were developed using the NCI-60 cell lines (http://dtp.nci.nih.gov/docs/cancer/cancer_data.html); however, when these predictors were applied to human data to predict response, the results were mixed [ 6, 7].
A complete tree with all branches is grown for each sample, and the predictors are applied to each branch [24].
These results show that PhosTryp, which was trained on Leishmania infantum, performs better than generic predictors when applied to this group of organisms.
Values of the nine predictors were applied to the equation as described in Table 1: 1 for men and 0 for women; 1 for presence of antihypertensive drugs, lipid-lowering drugs, and smoker and 0 otherwise.
The following genomic predictors were applied to these data based on published methods: the good/poor prognosis signature of Van't Veer et al.[ 4, 5] that is currently the basis for the Mammaprint assay by Agendia, the recurrence score 21-gene assay that is the basis for Oncotype DX[ 6, 7], and the recurrence risk (ROR-S) and subtype predictions based on the PAM50 assay[ 8].
