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Interestingly, reclassified MFH demonstrated similar patterns of oncogenic pathway activation as their corresponding predicted subtypes, providing further evidence that the 170-gene predictor reflects the overall molecular program in sarcomas, with therapeutic implications.
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Recent data support the concept that high-sensitivity C-reactive protein (hsCRP) is an inflammatory marker and independent predictor reflecting the early stage of CVD [ 6].
These predictors reflect the dominant role of side channel geometry (i.e., morphology of the upstream alluvial plug, slope conditions) in controlling their flooding regime.
Accordingly, we also identified the best measures in predicting ASD using a subset regression approach assuming 3 predictors reflecting the diagnostic triad.
Two predictors reflecting the socio-economic background of the girls were the median income of the neighborhood in which they were living (in quintiles), and a variable indicating whether they were entitled to preferential treatment or not.
The Bayes factor for each predictor reflects evidence for the null based on the full model compared to a model without the predictor (Rouder & Morey, 2012).
Indeed, 58 out of the 76 reclassified MFH samples (76%) clustered together with samples from their predicted STS subtypes suggesting that the 170-gene predictor reflects an overall 'molecular match' between them.
Here we estimate PCobs directly from the fraction of the variance that can be explained by model forecasts, diagnosed from the Pearson correlation (r) between observations ("predictand") and the ensemble mean of model hindcasts ("predictor") as r reflects the proportion of the predictand accounted for by the predictor [e.g., Wilks, 2006].
The reason was probably that V40 ratio is a more sensitive predictor and it reflects the interplay between changing total volume and V40 volume.
At this scale, data on fire history was available, and so a predictor reflecting burnt area was added to the final dataset.
FAME has other benefits since it is not just a predictor of CYP metabolism but reflects the broader enzyme reactions documented in the Metabolite database and can be filtered for Phase-I and Phase-II metabolism in human, rat and dog.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com