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Recent studies using DW-MRI to evaluate response to neoadjuvant chemotherapy showed that ADC was a significant and independent predictor of sensitivity to chemoradiation, with chemoradiation-sensitive tumours showing lower pre-treatment ADC compared with resistant tumours.
KRAS wild-type status is an imperfect predictor of sensitivity to anti-EGF receptor (EGFR) monoclonal antibodies in colorectal cancer, motivating efforts to identify novel molecular aberrations driving RAS.
We previously published a gene expression predictor of sensitivity to erlotinib, an EGFR inhibitor.
Therefore, the response signature was confirmed to also be a predictor of sensitivity to rapamycin.
Therefore, our study provides a favorable basis to use miR-21 as a predictor of sensitivity to platinum chemotherapy.
Sensitivity to thermal stimuli is a complex trait that has been used as a predictor of sensitivity to analgesic drugs.
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Using an independent dataset (n = 133) of breast cancer tumor samples from patients treated neoadjuvantly with combination (TFAC) chemotherapy, we validated the performance of the individual predictors of sensitivity to paclitaxel (T), 5-fluorouracil (F), adriamycin (A), and cyclophosphamide (C), as well as a combined predictor of TFAC sensitivity.
To identify which patients will respond best to particular combinations of treatments, biomarkers and gene expression profiles are being investigated as predictors of sensitivity or resistance.
Efforts are underway to identify molecular predictors of sensitivity or resistance to particular therapies by correlating various biomarkers to treatment response.
Despite the high disease control rate (DCR), gefitinib treatment is not curative and eventually there is disease recurrence, even in patients with predictors of sensitivity.
Even though I knew that the trials I'd just undergone might be a more complete predictor of taste sensitivity, it still vibrated with talismanic power.
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