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Nonetheless, we have previously demonstrated that, in obese children and adolescents, the degree of hyperleptinemia was a reliable predictor of responsiveness to an educational program of weight excess reduction [29], [30].
In general, internal consistency reliability is a poor predictor of responsiveness.
In contrast, we have now measured transcript levels at baseline as the single predictor of responsiveness.
Accordingly, ΔPP during PLR was proposed as a non-invasive predictor of responsiveness to preload in patients receiving mechanical ventilation.
We wished to confirm that a combination of the above transcript levels could be used as a predictor of responsiveness.
In agreement with the results of the current study, a prior study reported that tumor VEGF expression was not a predictor of responsiveness to bevacizumab therapy [ 26].
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This study was designed to determine the predictors of responsiveness to correction of vitamin D deficiency with oral vitamin D2 (ergocalciferol) in adults.
Age, sex, APOE, and AChEI administration were evaluated as potential predictors of responsiveness to AChEI treatment at the 6-month follow-up.
In addition, they have been identified as predictors of responsiveness to both gefitinib and erlotinib (Lynch et al, 2004; Pao et al, 2004).
This strategy will provide the highest chance of identifying genetic predictors of responsiveness to folate whilst simultaneously provide us with a resource, as knowledge of the genetics of these pathways increases, for future refinement and identification of other associations.
Little information on the use of these drugs in children has been reported; the identification of predictors of responsiveness to early conventional treatment may thus be beneficial for the accurate stratification of children and for improving outcome [ 13, 14].
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