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These data suggest that, although DHFR inhibition during TMQ exposure produced growth inhibition, DHFR catalytic activity 48 h after drug removal was a more accurate predictor of lethality in these two cell lines.
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KI-67 is a marker for cell proliferation which binds a nuclear antigen and is thus a prime antibody in immunohistochemistry. Scoring methodologies derived from KI-67 immunostaining have shown promise as predictors of lethality in a range of cancers [ 1].
For instance, shared localization, physical interaction and co-expression are some of the predictors of synthetic lethality [42].
The ATLAS score confirmed its value as predictor of outcome in CDI patients, for lethality, lenght-of-stay and direct costs of medication.
There is a risk of lethality here," she said.
Demonstrations of lethality by the Javelin and other weapons are profoundly appreciated here.
It was precisely at this time that the system reached its peak of lethality.
Each of these can also be upgraded to a second level of lethality.
But the hint of lethality, if not altogether gone, is likely to be attenuated.
GNPs caused a range of lethality when injected into mice.
Injection of surface-modified GNPs caused a spectrum of lethality in mice (Fig. 7).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com