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The most important requirement for a class predictor is that it predict accurately.
The clinical importance of a postchemotherapy and postendocrine therapy, tertiary risk predictor is that it could define the ER-positive patient population to whom new drug development should be targeted.
One that is especially important in the context of analyzing the performance of a predictor is that they only report a single statistic, namely, the similarity or distance between two terms or sets of terms.
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Prediction of any outcome depends on selection and accurate measurement of both predictor (be that a cognitive skill or a personality trait) and an appropriate outcome (for example, academic marks, skills, or professional behaviours).
The problem for predictors is that predicting swings in confidence is even harder than predicting swings in real phenomena, like earnings.
A prerequisite for the gain-cost evaluation to be prospectively meaningful as a tool for evaluating different predictors, is that the results on the training data also extend to new data.
The reason for choosing these predictors is that metabolite levels are the result of more genes than those represented by genetic markers, and as a rule they are also influenced by several genes and/or their products.
The main problem with sequence-based function predictors is that the number of false positives is high.
The underlying hypothesis of most B-cell epitope predictors is that certain amino acids have a higher likelihood of being part of a B-cell epitope.
Another advantage of the split sample method, particularly in large collaborative studies in which multiple groups will be developing predictors, is that the test set can be kept under "lock and key" by a honest broker [ 4].
One key advantage of genomic predictors is that they can be estimated early in the life of the animal and thus allow for increased accuracy of estimated breeding values (EBV), particularly for young animals, which have not yet produced progeny.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com