Sentence examples for predictive safety from inspiring English sources

The results were later folded into the Critical Path Initiative's Predictive Safety Testing Consortium, officially established in 2006, that enables member companies to share internally developed laboratory methods to predict the safety of new treatments before they are tested in humans.

As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices.

Nonetheless, the promise of metabolite profiling as predictive safety assessment tool seems clear and merits further exploration and use.

First, cardiotoxicity and hepatotoxicity are among the most prevalent causes for drug attrition in clinical trials, and improvements in preclinical predictive safety testing are highly desirable.

Both individual laboratories as well as international research projects, such as the Safer And Faster Evidence-based Translation (SAFE-T) consortium (started under the European Union Innovative Medicines Initiative) and the Critical Path Institute's Predictive Safety Testing Consortium, are evaluating novel biomarker approaches (for a review see [ 2] and Table  1).

Conclusions: Neuropsychologic and medical information available by traditional methods showed unique value in predictive driving safety.

The research should be performed in relevant disposal environments with the ultimate objective to quantify those effects that need to be included in models for predictive and safety assessment purposes.

Although many of the mechanisms of adjuvants have been elucidated, meaningful comparisons between different adjuvants derived from in vitro studies, or from studies using adjuvants in rodents or other animals, are often not predictive for safety, adjuvant effects, or vaccine efficacy in humans.

67 It should also be noted that previous studies have indicated that a low antibody titer is not predictive of safety or efficacy issues.

Further RCTs are needed to determine optimal intensity, frequency, duration and position of vibroacoustic stimulation, as well as efficacy, predictive reliability, safety (in terms of fetal hearing impairment and neurological development) and perinatal outcome.

The goal for new predictive translational safety biomarkers is to be able to monitor early indications of organ toxicity in clinical trials, so better informed clinical and regulatory decisions can be made and treatment can be stopped or altered before organ injury occurs (Aronson 2005; Matheis et al. 2011; Sistare and DeGeorge 2011).