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Rotation was detected in 21 patients, retroversion in 17, and anteversion in 4. Preoperative systemic BMD was predictive of the magnitude of stem subsidence (p = 0.007).
Gene expression analysis was performed at all three timepoints to identify early gene signatures predictive of the magnitude of the subsequent adaptive T cell response using the significance analysis of microarrays (SAM) statistical package and gene set enrichment analysis.
This is a prospectively designed study to determine if quantitative levels of the ERBB2 gene expression level as assessed by mRNA coding for the HER2 protein, quantified by the 21-gene assay and reported as the HER2 single gene score, are predictive of the magnitude of benefit from the addition of trastuzumab to adjuvant chemotherapy in NCCTG (Alliance) N9831.
IHC4 correlates reasonably closely with Oncotype Dx (72%) (Cuzick et al, 2011), and for this reason it is likely to also be predictive of the magnitude of benefit from chemotherapy in the same way that Oncotype Dx is demonstrated to be (Paik et al, 2006; Albain et al, 2010).
The primary aim of this prospectively designed study was to determine if quantitative levels of the ERBB2 gene expression level as assessed by messenger RNA coding for the HER2 protein quantified by the 21-gene assay and reported as the HER2 single gene score are predictive of the magnitude of benefit from the addition of trastuzumab to adjuvant chemotherapy in NCCTG (Alliance) N9831.
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Next, we tested whether the probabilistic tract-strength of this connection was predictive for the magnitude of bias in a perceptual decision-making task.
In contrast, the "cognitive" model, where risk perception is conceptualized as an antecedent of affect, seems to be better specified in terms of predictive ability given the magnitude of the personal experience to risk perception path (nearly double) and improved R = 0.05.
However, this selection procedure does not make possible an exact comparison of the magnitude of the predictive abilities of the Shc proteins (HR and RR) between the two studies.
The anti-EXE antibodies had no predictive effect on the magnitude of an individual's glycemic response or the incidence of adverse events.
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On the other hand, recent changes in employment and marital status were relatively rare life events, and were not strongly predictive of these disorders, so the magnitude of attenuation when considering each of these variables was minor.
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