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Carboxyhemoglobin (COHb) levels are not predictive of severity or prognosis.
In the post-HAART era, minor-motor neurocognitive disorder and depression are more predictive of severity of HIV-dementia later in the disease course.
Copeptin was also a more reliable diagnostic marker of sepsis than AVP in this study, as it was described as predictive of severity and outcome with more sustained blood levels than AVP in earlier works [ 12- 16].
However, female gender and low hemoglobin levels, which prior studies have found to be predictive of severity of fatigue [ 24- 26], were not associated with fatigue in our study.
Similarly, in individuals at high clinical risk of psychosis, Sabb and colleagues [ 43] found that baseline neural activity in the left inferior frontal gyrus during performance on a language processing task was predictive of severity of positive formal thought disorder and poor social outcome at follow-up.
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Furthermore, patients with more severe COPD demonstrate greater increases in airway and systemic inflammation during exacerbations than those with milder COPD, indicating that baseline severity of COPD is predictive of exacerbation severity [ 19].
Unfortunately, early reliable and sensitive predictive markers of severity are not at hand for application in clinical practice beyond popular multifactorial scores [22 24].
Further kinetics studies are required to define whether elevated MP numbers can be considered as a predictive marker of severity for malaria patients.
Reduced MMP-9/TIMP-1 rando and increased MMP-10 levels may represent new predictive biomarkers of severity in these patients.
We were surprised that the predictive ability of severity of illness and clinical comorbidities was so small relative to that of hemoglobin.
On the other hand, we revealed a strong predictive power of severity of acetabular bone defects (i.e. size of osteolysis) for aseptic loosening of the ABG I cup.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com