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IP JSN was negatively predictive of sCOMP concentrations.
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These plots again demonstrate the positive association of sCOMP with OST, but a negative association, with the exception of JSN of the CMC, of sCOMP with JSN.
Levels of sCOMP and serum C-reactive protein (CRP) were measured in 150 patients.
Levels of sCOMP were not significantly associated with CRP (P = 0.78).
Elevated serum levels of sCOMP showed a significant correlation with the progression of the Larsen score within 5 years in a patient group with established RA, and sCOMP is also described as a prognostic factor in early RA [ 3, 4].
Inflammatory synovium has been considered a potential tissue source of sCOMP since the molecule has been detected in the synovium in both RA [ 5, 6] and osteoarthritis [ 6].
In our patient group elevated levels of sCOMP could only be detected in patients with RA and in a few patients with PsA, but not in patients with reactive arthritis, with Raynaud's syndrome, with scleroderma, with systemic lupus erythematosus, with leucozytoclastic vasculitis or with Sjögren's syndrome.
Piscoya et al. [ 14] have shown increases in COMP production in response to dynamic mechanical load in cartilage explants, and acute bouts of moderately intense physical activity have been shown to temporarily increase the concentration of sCOMP in healthy individuals [ 15] as well as those with knee OA [ 16, 17].
Some came from backgrounds predictive of reading difficulty.
"What is predictive of elections are ideas and message".
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