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Anglicheau, D. et al. MicroRNA expression profiles predictive of human renal allograft status.
A big part of the problem is that animal models are not particularly predictive of human efficacy".
With luck, scientists may also learn how to alter mice so that they metabolize toxic substances and therapeutic drugs more as we do, making animal tests more reliably predictive of human reactions than they now are.
And so it's going to be a long time coming before we have reliable systems that are predictive of human response.
These considerations are especially relevant in designing preclinical animal models of TBI that are more predictive of human responses and outcomes.
To present findings that gender might be more predictive of human immunodeficiency virus (HIV) and sexually transmitted disease (STD) knowledge, and sexual behaviour, compared with participation in knowledge-based HIV prevention programmes.
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This approach is of interest to drug development as detection of positive selection in a drug target or members of a disease pathway may cause animal models to be non-predictive of human biology and explain some observed biomedical differences between species [ 21].
Conclusions: This prospective study confirms an excellent sensitivity and negative predictive value of human papillomavirus deoxyribonucleic acid testing after conization in predicting residual cervical neoplasia.
Interestingly, many of the predictive descriptors of human disease genes identified by Kondrashov et al. [ 12] were identified in our study as being predictive of microbial essential genes.
After exploratory analysis, 29 were selected to build a predictive model of human fire ignition using logistic regression analysis.
Sensitivity, specificity, and positive predictive values of human papillomavirus testing for biopsy-proven HSIL were 87.5%, 72.5%, and 11.3%, respectively.
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