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A tree trained using this definition contained many of the substructures present in the original tree and was similarly predictive of activity in independent assays despite the exclusion of 75% of compounds defined as active under the more permissive definition of activity (Fig. S9).
Longitudinal study of the ICF component relationships showed a feedback pathway indicating that the level of participation restrictions at baseline was predictive of activity limitations three years later.
Epigenomic divergence is often attributable to genetic variation within TF motifs at orthologous enhancers, with a novel motif being most predictive of activity biases.
Ascites models have been found to identify drugs active against rapidly dividing tumors; however, neither ascitic nor transplantable subcutaneous tumors are predictive of activity for solid tumors.
A visual analysis of the PCs for RXR clearly displayed that Autodock Vina outperformed Surflex-dock and ICM in terms of early enrichment and that its scoring function would be more predictive of activity within its high scores.
Also predictive of activity was the personal importance of exercise.
Similar(52)
Importantly, the presence of either TAL1 or GATA1 was also highly predictive of enhancer activity, with median activity levels comparable to that for EP300-positive DNA segments.
CMCase activity was not predictive of saccharification activity, as supernatants from T. aurantiacus showed up to 11.5-fold lower activity on CMC compared to supernatants from T. terrestris.
We examined demographic variables, including age, sex, and socio-economic status, that have already been shown to be predictive of physical activity, or change in physical activity [ 20].
Although these are important models for prediction of mechanisms of action, they are less predictive of clinical activity.
A comprehensive translational medicine plan is included in this trial with the aim of identifying predictive markers of activity.
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