Exact(2)
Distal to gene promoters, H3K4me1 and H3K27Ac have been used as predictive marks of enhancers, which regulate the transcription of their target genes in a distance and orientation independent manner.
In our study, we have broken up RNAPII recruitment and elongation and found that the most predictive marks for both the processes are H3K4me2, H3K4me3, H3K9ac and H3K27ac, but the location of the marks have different predictive importance for respective processes.
Similar(58)
Principal Investigator, Use of Plasma D-Dimer as a Predictive Marker in Colorectal Carcinoma: Correlative Science Study with Genentech, Inc. Principal Investigator, A randomized, Phase II study of gabapentin or glutamine to prevent the peripheral neuropathy/myalgia associated with weekly taxol administration in metastatic breast and lung cancer.
To determine how the DNase I identification of putative cis-regulatory elements compares with other predictive epigenetic marks, we carried out a more detailed analysis of the developing brain.
Not a terribly predictive marker.
The present paper discusses the evolution of models describing the nanostructure of the calcium silicate hydrate (C S H) over the past century (descriptive models), with a focus on the models presented in the last fifteen years, 2000 2014 (descriptive and predictive models), marked with the breakthrough of nanotechnology.
As for the JSD, a large value indicates a large distance between the joint predictive distributions, marking the measurement as useful.
In a study conducted in adipose tissue [ 29], meQTLs overlapping metabolic disease loci were enriched in histone marks predictive of genetic enhancers.
The effects of early life exposure to a maternal LP diet were specific to the enhancer region - with recruitment of the repressive mark H3K9me2 and loss of a mark predictive of active enhancers, H3K4me1.
Sensitivity, specificity, positive and negative predictive values of marked T2 hyperintense signal with delayed persistent enhancement are 85.2, 87.5, and 88.5 and 84%%, respectively, for the diagnosis of inflammatory HCAs [41].
Comorbidity has also demonstrated marked predictive power for survival and treatment allocation among prostate cancer patients.
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