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Although we hypothesized, according to previous findings, that patient-related factors such as BMI and previous abdominal surgery were predictive for the type of surgical approach, we could not confirm this in our study [24, 25].
Taking the prognostic value and the potential predictive value of serine proteases into account, we hypothesised that tumour-associated PMN-E might be predictive for the type of response to systemic treatment in patients with advanced breast cancer.
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Once identified, by either in vivo or in vitro methods, a system can be developed to detect and to evaluate predictive ability for the type of in vivo neurotoxicity produced.
The model was predictive for the major types of NSCLC – ADC and SCC, and performed reasonably satisfactory in two independent patient cohorts.
In conclusion the possibility of a wide (R0) resection and the absence of pathological fractures and visceral metastases were predictive for longer survival, whereas age and the type of orthopaedic surgery had no impact on survival.
Notably, the models were predictive for different types of networks suggesting that it may be applied to mixed networks of biological interest.
For this reason, as well as the reasons described above, nine markers predictive for both types of PE were selected for further prediction modeling.
As the modeling for early- and late-onset-PE was executed separately, it is interesting to find that a single marker is predictive for both types of PE, that is, the entire clinical range, which would fit in with our aims.
Our first aim was to investigate whether the type of progression event was predictive for OS in Study 301 and Study 305/EMBRACE.
In this study, we therefore kept the distinction between EO- and LO-PE, as in previous studies on this cohort [ 8, 13], but with an aim of identifying markers predictive for both types of PE.
Other researchers, however, have found that the type of haematological malignancy was not predictive for mortality [ 13, 16].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com