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All external predictions were ranked between position 3127 and 11762 on the ranked list of the prediction values of 15,006 compounds.
Predictions were ranked by the average of the figure-of-merit statistic from D.melanogaster and D.pseudoobscura.
Predictions were ranked based on the context + scores of the sites that represent the predicted efficacy of targeting [ 50].
In the resulting subset, predictions were ranked according to precursor positions and sequence similarity, and to target identity.
When the 200 different predictions were ranked according to the annual number of cases in the period 1983 87 (frequency), the cut-offs for the four quartiles were 70, 230 and 555.
In addition, five of the affinity density predictions were ranked higher than 100, compared with only two of the conserved motif cluster predictions that were ranked higher than 200, suggesting higher specificity in the affinity density algorithm.
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In mammals, predictions are ranked based on the predicted efficacy of targeting as calculated using the context scores of the sites.
Predictions are ranked using site number, site type, and site context, which include factors that influence target-site accessibility.
The overall predictions are ranked in 16 precursor position groups.
Predictions are ranked by their confidence scores (details in Methods) assigned by MESSA.
Results of this comparison are summarized in Figure 4: for every method predictions are ranked according to the parameter assessing how good the latter are.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com