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Using bioinformatic predictions, we identified a set of 117 predicted H-2 IAb binding peptides in 7 proteins targeted by B cell responses.
Based on the experimental data and computation predictions, we identified TPP-6-ISA as a candidate drug with optimized antiapoptotic potency.
On the basis of further sequence predictions, we identified a segment (residues 218 266) in the apoE CT domain that bears a high propensity to form a coiled-coil helix, which coincides with the putative lipoprotein-binding surface.
To empirically test our predictions we identified P. knowlesi orthologs of genes in the literature-derived invasion cluster.
From database searches and gene predictions, we identified 53 and 95 putatively functional (i.e. not disrupted by stop codon and/or frameshift) OR genes in medaka and stickleback, respectively.
Using signal peptide predictions, we identified 99 secreted homologs across 97 species.
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To test this prediction, we identified 166 "tag SNPs" that separate 12 of the haplotype clades in non-Africans (OOA) from the cosmopolitan haplotype clades shared between Africans and non-Africans (COS) and for which we had data from the Neandertals.
Combining expression profile information with miRNA target prediction, we identified miRNA-mRNA pairs that correlate with ES cell pluripotence and differentiation.
Based on BLASTn search against the cucumber genome and hairpin structure prediction, we identified genomic sources of miRNA and potential precursors for the totality of the new and candidate csa-miRNAs.
By the combined in silico approaches of expression profiling and localization prediction, we identified putative components of the intracellular network related to xylan synthesis and secondary wall development and proposed models for their function and interactions.
To verify this prediction, we identified the genes that were differentially expressed between any two of the four populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com