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The process requires women take their body temperature at least several times a week, and do so first thing in the morning, inputting the data into the app which is designed to adapts its 'fertile' or 'not fertile' predictions to each user's cycle.

Nevertheless, groundbreaking work presented at this exciting conference exemplified the current potential of these approaches to produce systems biology models of biological interactions, explore sources of biological heterogeneity and emerging regulatory mechanisms, and inform disease prognosis and outcome, potentially tailoring predictions to each individual.

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When possible the sixth step assigns an homology-driven, function prediction to each VC.

DOI: http://dx.doi.org/10.7554/eLife.05005.021 3P-seq data were available for seven developmental stages or tissues of zebrafish, enabling isoform profiles to be generated and predictions to be tailored for each of these.

We compare these predictions to patterns currently displayed in each population.

We compared the models' predictions to the true phenotype of each validation sample, and then calculated sensitivity, specificity and accuracy.

We have used our oriC and dif sites predictions to determine the polarity of each gene respective to the orientation of the replication forks (Fig. 3 and Suppl. Fig. S2).

It allows the user to display a graphical repository line for comparison among different predictions, to highlight zones of interest, to retrieve sequence boundaries for each prediction and to extract parts of sequences corresponding to a prediction or a highlighted area.

Having determined the posterior distribution of model predictions, there is now a direct link between different predictions and parameters, which can be exploited by determining how predictions relate to each other and to the model parameters.

How do their predictions compare to each other and to manually curated atom mappings?

To analyse difference in predicted CXCR4 usage of CRF02_AG and HIV-1G, the results of the coreceptor predictions according to each rule/tool were analysed for differences using Fisher's exact test, as implemented in GraphPad Prism version 5.00 for Windows, GraphPad Software, San Diego California USA, www.graphpad.com.

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