It must be point that, of the 1190 * 26,489 ligand-target pairs in test set, Morgan model with threshold (10 upmu {text{m}}) gave 65,772 pair of positive predictions (P value (le 0.05), and most of these predictions haven't been proved by experiment.
For both personal PM2.5 of ambient origin and total personal PM2.5 calibration coefficients, we found no statistically significant evidence of heterogeneity across cities for outdoor home model predictions (p-values = 0.11 and 0.17, respectively) and therefore results from Model 2, instead of Model 1, can be used.
We found significant effect modification by season for outdoor home model predictions (p-value = 0.006), with season-stratified calibration coefficients higher during winter (0.60 (95% CI 0.36, 0.64)) than summer (0.50 (95% CI 0.42, 0.78)).
The median of the predicted conformal prediction p-values for each class (active or inactive) across all iterations is then used to derive the predicted labels.
The detailed enzyme names, gene IDs, KEGG prediction P-values and their typical catalytic reactions are shown in Table S1, and the ratios of the pathway groups are shown in Table S4.
To test this hypothesis, we first applied a less stringent version of Poscons TFBS prediction (p-value corresponding to 1 hit every 25 kb), which increased the number of SNPs in HRM sites by a factor of ∼1.8 in each population.
To estimate the statistical significance of the prediction, P-values were calculated from one-sided Fisher's exact tests (Mehta and Patel, 1997).
The correlation of the predicted P-value {i.e. the minimal P-value that was reported from any of the MDBs that support such prediction, transformed to [1-log P-value)]} with the fraction of MDBs or the input hits is quite significant (R = 0.496 and R2 = 0.419, respectively).
AS-OCT had good agreement with auto-refractor with at least 95% of the measurements within the prediction interval (P value <0.001).
All the predictions are significant (p value < 0.0001).
We obtained the more informative predictions with a P value = 0.05 than with others, especially those with a larger value.
