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At the same time, these results are not inconsistent with the predictions of selection resulting from pollinator/mate-limitation associated with the traditional reproductive assurance hypothesis.
Our results suggest that accurate predictions of selection response for disease risk and severity require a thorough understanding of the structure of genetic variation, i.e., of the source of genetic variation and the shape of the corresponding distributions.
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A nonrandom relationship between body size and island area, as seen here, is an explicit prediction of selection for optimal body size due to indirect island area effects on resource availability and community composition [4], [16], [17].
Our study has implications for the biological interpretation of field data, and for the prediction of selection response from breeding for nematode resistance.
Several studies have developed methods to incorporate functional information on codon and amino acid substitution to provide a more integrated prediction of selection (reviewed in [ 23]).
Examples include selection from inbred base populations to test the contribution of mutational variance in quantitative traits and prediction of selection response from genetic variation present in the base population (Hill and Caballero 1992).
Among the parameters characterizing the angling fishery, q (catchability) and p (proportion of maximum angling effort always present) were found to be particularly sensitive for prediction of selection pressures.
Recent studies using these codon models of evoluton in an ML framework have combined evolutionary predictions of positive selection with biochemical verification of functional affects of these substitutions [ 14- 16], and thus support the link between positive selection and protein functional shift.
Further the morphologically based results enable predictions of size selection of red mullet in codend designs not previously tested experimentally.
Sequencing error may have important consequences not only on estimates of absolute rates of mutations, but on phylogenomic analyses that depend on the relative rates of events, as in the identification of novel functional elements and in predictions of positive selection [20], [21].
False positive predictions of positive selection will be more frequent in poorly aligned or sequence error-prone sequence [ 73].
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