Sentence examples for predictions of pathway from inspiring English sources
We then show via an analysis of the kinetic binding rate constants how the results of experimental manipulations, modeled as changes to certain of these binding constants, lead to predictions of pathway output consistent with experimental observations.
Making quantitative predictions of pathway function requires a comprehensive set of high confidence parameters.
In addition, predictions of pathway activities in a third independent data set provided further confirmation for the patterns of pathway activity typical of a given intrinsic subtype [see Additional data file 1].
We have now made use of these pathway signatures to aid in characterizing breast cancer subtypes, and predictions of pathway activation were performed by using each of the previously described pathway signatures [ 6].
Previous work showed that the prediction of pathway activation can coincide with sensitivity to drugs that target a component of the pathway [ 8, 25, 26].
The results show that prediction of pathway cross-talks by FBA is robust and reproducible even though the pathways curated by different databases are diverse.
When applied to a particular pathway, flux balance analysis (FBA) allows the prediction of pathway capability, and, by in silico deletions and overexpression analysis, examination of the potential regulatory steps and, hence, candidate drug targets [ 8, 9].
We demonstrated the prediction of pathways related to a user-defined protein network.
However, in our computational prediction of pathways in F. tularensis subsp. tularensis suggests that it has pathways for synthesis of all amino acids except Arg and His.
Reliable and consistent predictions of oncogenic pathway activities can be obtained from FFPE tumor tissue samples.
Our results reveal that, not only does this technique corroborate previously published data on p68 and p72, it also generates testable predictions of novel pathway partners of p68 and p72.
