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The predictions mentioned above might reveal multiple candidates each requiring a separate validation experiment.
This means that much of the ambiguity regarding model predictions mentioned above is eliminated.
The experimental SPR responses shown in Fig. 2a and obtained in the 2 × SSC buffer solution are in good agreement with the theoretical predictions mentioned above.
The nuclear results contrast with some previous empirical studies [ 14, 29], and also contradict theoretical predictions, mentioned above, that the evolution of selected sites should be relatively immune to variation in life history [ 71].
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The in silico prediction mentioned above was based on the alignment of the reported miRNAs of human, mouse and rat to the porcine genomic sequences.
Further studies that would include measurement of membrane stability are needed to confirm the prediction mentioned above.
According to the functional site prediction mentioned above, we were able to determine that these six residues (Ser146, Ser168, Thr174, Leu189, Leu264, and Tyr276) are involved in the formation of the active site.
37 Moreover, it was found that CST complex not only stimulates semi-conservative DNA replication, but mediates the coupled reaction of primer synthesis and templated DNA synthesis in Xenopus egg extracts, a finding consistent with the prediction mentioned above.
As for more complex methods, an extremely important feature of the present study is the potential for a 'paradigm shift' in prediction, mentioned above in relation to neural network models.
All the methods mentioned above are applicable for the site of metabolism prediction but do not estimate the structure of the metabolites.
Despite the inherent complexity in designing a prediction system only by means of computational chemistry, the recent methods mentioned above have made a remarkable advance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com