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Our methodology and the high-confidence DDI predictions generated in this study can help to better understand the functional significance of PPIs at the modular level, thus can significantly impact further experimental investigations in systems biology research.
We believe that our methodology and the high-confidence DDI predictions generated in this study will help to interpret the functional significance of PPIs, and thus enhance the utility of vast amount of the 'binary' protein interaction data generated from high-throughput experiments.
The datasets and predictions generated in this study provide a guide for future experimental characterization of the Hmd protein family.
Experimental corroboration of the predictions generated in this study is therefore needed, particularly in prostate tissues or cell lines.
The most effective model configuration was determined by examining the wage predictions generated in the 2006 labour force survey data which were evaluated by calculating the standard deviation of the residuals of the predicted wage subtracted from the actual wage.
Although the predictions generated in this study should be treated with a degree of caution, these observations would agree with the hypothesis of a cancer susceptibility mechanism mediated by c-MYC germlineoverexpression.
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It is also important to understand that the testable hypotheses and predictions generated by in silico computational modeling with the reconstructed model should be evaluated experimentally.
Certainly for its size, our estimate of bite force in Andalgalornis is relatively weak compared to predictions generated for anterior bites in carnivorous mammals.
Accuracy is highest and variance is lowest in breakthrough predictions generated by the MLE-based rock-physics transform.
Such predictions generated by models that take in input surveillance data are used for public health decision making and system design.
These predictions generated 418 PSEP-encoding genes in the genome of Me. pennsylvanicum.
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