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When a corpus was used to generate multiple predictions, for instance by different teams of a community challenge, it is interesting to check various run combinations or construct an ensemble systems with improved performance over the best single run.
Mathematical methods of biochemical pathway analysis are rapidly maturing to a point where it is possible to provide objective rationale for the natural design of metabolic systems and where it is becoming feasible to manipulate these systems based on model predictions, for instance, with the goal of optimizing the yield of a desired microbial product.
PicTar (14) predictions, for instance, are still based on the miRBase release 5.0 annotation (2004).
We expect to find off-label indications in the predictions for instance, as well as false positives.
Sometimes, it is not possible to formulate specific predictions, for instance, when one is interested in individual differences in calling, where it may be difficult to predict the type of variation that can be found.
Filtering successfully reduced potential false positive predictions, for instance, a large fraction of oxidoreductases (all binding the cofactor NAD) obtained by screening with the least specific 'Rossmann-fold domain' HMM were removed after the fold recognition based filtering.
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The prediction, for instance, that 2012, the end of one of their immense and minutely calculated calendar cycles, will bring the end of the world.
Researchers and practitioners alike face various types of challenges when using big data analytics for prediction, for instance, privacy and security of big data [17], platform scalability, integration, etc.
Such a model should be chosen judiciously, however, because some methods for genomic prediction, for instance, in the machine learning field, lack explicit underlying models.
28 30 31 The original models were developed for different time periods of risk prediction (different "prediction horizons")—for instance, some models estimate 5 year risk and others 10 year risk.
To reduce the number of false positive predictions to for instance 3%, we would only be able to retrieve 48% of true positives (see Supplemental Table S3).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com