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In principle, the optimized conformation of the isolated peptide could be used, however this did not improve the binding affinity predictions (data not shown).
For other test cases, the removal of this minimization step lead to less discriminative (as reflected by higher p-values), or even wrong predictions (data not shown).
We also attempt to combine the consensus results of two predictors by voting; but it does not work as good as the best individual predictor in the phi/psi angle predictions (data not shown).
The genotype frequencies did not deviate from the Hardy-Weinberg predictions (data not shown).
Some of the intron positions displayed inter-species conservation which supported our predictions (data not shown).
During the OLE study, pharmacokinetic concentrations of tabalumab closely aligned with RCT1 and RCT2 model predictions (data not shown).
Similar(48)
As such, the genes in the metagene model have no predictive power for survival prediction (data not shown).
Both drugs exhibit good oral bioavailability and mostly negative result in Ames test as predicted by FAF-Drugs2 and PreADMET toxicity prediction (data not shown) and no evidence of carcinogenic activity for only DB04698 as predicted by PreADMET rodent carcinogenicity prediction.
As expected, the differences in number of ORFs between the three strains were much smaller when the same methods were applied for ORF prediction (data not shown).
We have assembled a considerable amount of additional evidence supporting this prediction (data not shown).
Replacing ChDXR1yr with Z-scores to account for age related bone loss did not improve prediction (data not shown).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com