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This contributed to the improved accuracy in negative predictions by increasing the number of true negatives.
This accomplished the desired effect of improving pharmacokinetic predictions by increasing the in vitro intrinsic clearance rate, CLint (Vmax/ Km) to more closely match what is seen in vivo.
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Additionally, for the other SVs, the SHEAR pipeline improves the confidence of the CREST prediction by increasing the number of soft-clipped reads that are concordant with the breakpoint pairs.
Points correspond to empirical averages over bins of 60 predictions (ordered by increasing uncalibrated probability).
After the initial feature selection, we measured AUC of each prediction algorithm by increasing the number of features (5 ~ 1000 SNPs) used for the prediction.
Consequently, the heterogeneity of the data sets generated from different laboratories and with different microarray technologies, was not the only, perhaps even not the major limiting factor for improving prediction accuracy by increasing sample size.
Genomic selection makes it possible to reduce pedigree-based inbreeding over best linear unbiased prediction (BLUP) by increasing emphasis on own rather than family information.
A number of studies have compared the effect of SNP density on genomic prediction, mainly from low- to medium-density, based on simulation or real data analyses and have shown a considerable improvement in prediction accuracy by increasing the density of SNP arrays, e.g., [ 6– 10].
Thus, the accuracy of predictions is improved by increasing the size of training populations and the intensity of selection is increased by genotyping a larger number of selection candidates.
As shown in Figure 2, the minimum accuracy of SIPHT predictions can be improved by increasing the stringency of the search parameters; however, as discussed above, this increased accuracy will often result in reduced sensitivity.
By predicting fewer fragments, Basophile potentially could fail to match observed fragments; by increasing prediction accuracy, Basophile gains identifications by reducing false positive matching.
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CEO of Professional Science Editing for Scientists @ prosciediting.com