In addition, 40 participants did not have PM2.5 predictions and an additional 36 did not have NOx predictions, leaving a maximum of 6,140 participants for the PM2.5 analysis and 6,104 participants for the NOx analysis.
In this context, it is important to emphasize that all these potentially pathogenic variants represent in silico predictions and usually additional information is needed to identify the disease-causing mutation(s) in a particular case and family.
Nine sequences were manually edited to correct putative errors in their protein predictions, and an additional seven sequences were removed from the dataset entirely, due either to errors that could not be resolved or to redundancies in sequences retrieved by BLAST (See Additional file 2).
The total number of novel multifunctional proteins is expected to increase as refinements to gene prediction software and additional EST data identifies both multi-exonic proteins and adjacent genes on the genome as single gene models.
These estimated net increases are somewhat higher than the observed increases in 5-year survival in CC and RC during the study period (ie, 7.7% and 7.1%, respectively), likely resulting from imprecision in the prediction model and additional unmeasured influences that had a small net negative impact on 5-year survival during the study period.
We realize that we could not do a formal statistical validation of the model, since the 'observed' data themselves are partly based on model predictions (by WHO) and additional assumptions.
Methods for predicting protein secondary structures provide information that is useful both in ab initio structure prediction and as additional restraints for fold recognition algorithms.
We found strong support for the condition-dependent prediction and some additional support for the classic prediction, although only when condition dependence was also considered (Table 5).
To expand on this point, a well-designed control algorithm uses several consecutive CGM values, computes trends (typically via model prediction), and uses additional data sources, such as information from the insulin pump.
