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By considering the kinetics of convergence one can ensure that this space can be explored rapidly, resulting in computationally efficient structure prediction protocols.
A few studies have also been presented where molecular docking, i.e. a computational method for predicting binding between a ligand and a protein, has been used in redocking experiments [25], [26] and in affinity prediction protocols [27].
Then by using the 'Clustering tool' they could create, and later download, a nonredundant data set, which will be the base of work for extraction of structural descriptors needed in a classic phosphorylation prediction protocols.
Contact: [email protected] Template-based modeling (i.e. homology modeling and protein threading) is becoming more powerful and important for structure prediction along with the PDB growth and the improvement of prediction protocols.
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To increase the stringency of the target prediction protocol, we searched for mRNAs simultaneously predicted by five or more different target-prediction programs.
Figure 5 shows the MemBrain-Rasa prediction protocol [8].
The realised target prediction protocol is available at https://github.com/lhm30/PIDGIN.
Open image in new window Fig. 5 The flowchart of MemBrain-Rasa prediction protocol.
The realised target prediction protocol has been packaged and available for download at https://github.com/lhm30/PIDGIN.
Our structure prediction protocol RAGTOP (RNA-As-Graphs Topology Prediction) represents RNA structures as tree graphs and samples graph topologies to produce candidate graphs.
To identify novel phosphopeptide substrates of PTP1B, we developed a computational prediction protocol based on a virtual library of protein sequences with known phosphotyrosine sites.
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