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Although it was not a primary goal, this update also improves the accuracy of model prediction of viability and auxotrophy phenotypes and increases the number of epistatic interactions.
This update also improves the accuracy of model prediction of viability and auxotrophy phenotypes and increases the number of epistatic interactions.
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The computer program required for FBA is available in Additional file 9. Along with the biomass composition and stoichiometric information about a metabolic network, computational predictions of viability require information about the chemical environments that contain the nutrients needed to synthesize biomass precursors.
Receiver operating characteristic curves were generated for PTF, PTI and MBF for the prediction of myocardial viability assessed by LGE CMR.
In addition, cell death kinetics is typically applied to prevent an over-prediction of cell viability in lignocellulosic process (Zhang et al. 2009a, b).
Reliable predictions of the viability of endangered species under a variety of management scenarios are of vital importance in conservation ecology.
Specifically, the two goals of expanding the reconstruction of metabolic networks and improving model predictions of mutant viability may be contradictory in some situations.
Results of in silico viability prediction of deletion strains of S. cerevisiae.
Results demonstrate similar performance to that of previous reconstructions in terms of the accuracy of prediction of single gene knockout viability (Table 3).
As evidence of improvements to the consensus yeast reconstruction, we have presented a comparison of viability, auxotrophy predictions, and genetic interaction effects, produced using FBA of the Yeast 5 GEM and other metabolic models (Table 1).
Changes to the data collection processes, such as changes to the attributes of the collected data, could impact the predictions and the viability of producing predictions in the first place.
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