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The study links modified penetrance to specific diseases at the genome-wide level, which has exciting implications for future prediction of the severity of serious diseases such as cancer and autism spectrum disorder.
The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians.
While none of the variables were predictive of the frequency or intensity of head pain, measures of anxiety, perfectionism, and life stress events contributed significantly to the prediction of the severity of head pain.
Studies of splice site mutations are highly relevant in order to identify a correlation between the effects of splice site mutations and patient phenotypes, to enable a prediction of the severity of the disease, and to design therapies.
Prediction of the severity of the symptoms of fragile X syndrome is limited.
Prediction of the severity of joint inflammation at an early stage is important to optimise treatment strategies in patients with RA.
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Computational predictions of the severity of missense substitutions were made using PolyPhen [29] and SIFT [30].
The distance of the actual prediction to the decision boundary (0) reflects the reliability of the prediction and the severity of the predicted effect (large distance = high reliability and severity [ 17]).
Our data support the importance of NVC not only for the early diagnosis of SSc, but also in the evaluation and possibly prediction of the severity and organ involvement of SSc.
Indeed, outcome prediction models measuring the severity of illness of patients admitted to the ICU use physiological variables to predict hospital mortality.
Blood methamphetamine concentration may be a helpful value for assessment of the severity of intoxication and prediction of clinical outcomes.
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