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Here we present a systems biology-based strategy that allows prediction of shared and differential effects of drugs.
Gene expression profiles across multiple tissues allow the prediction of shared functional properties of animal and human tissues including prediction of tissue-specific drug responses.
When a possible evolutionary relationship between two proteins seems to depend on the prediction of shared "mixed beta-strands and alpha helices" (line 373), it is hanging by a very thin thread indeed.
Overall, we interpret results of these Structure analyses as an evidence of relatively low levels of admixture between the six Vibrio species, and consider the initial prediction of shared ancestry between V. jasicida and Vibrio sp. as a result of too little data available to find a true genetic structure of the 35 strains.
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Conserved primary sequence is indicative of an underlying conserved tertiary structure, and the evolutionary information contained in an alignment of related sequences can be leveraged to improve predictions of shared structures [ 16].
The mortality prediction of SHARE-FI75+ was similar to that of the other SHARE frailty scales.
The mortality prediction of SHARE-FI75+ was compared with that of previously operationalised frailty scales in SHARE (SHARE-FI, 70-item index, phenotype, FRAIL).
In addition, we imputed missing mortality data and conducted a sensitivity analysis to assess the impact of missing mortality data on the mortality prediction of SHARE-FI.
Theoretical predictions of the proportion of shared k -mers, ph, calculated from the observed frequency distribution of k -mers, Q k, for the tropical trees dataset ranging in size from 400 M to 1.3Gbp assuming the true distance between taxa is d = 0.1 (divergence time 94Mya).
In this paper we test this prediction using both feeding data of shared predators and population dynamics data of the prey species.
Our analysis demonstrated that: (i) for about 18%% of the human genes, the expression in lung can be predicted by an assessment of the gene expression in blood, and (ii) the efficacy of the prediction depends on the number of shared eQTLs.
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