Your English writing platform
Free sign upExact(32)
While there have been great advances in predicting protein structure from primary sequence (see later), the prediction of function from structure (let alone sequence) remains an important (if largely unattained) aim.
With the present modality, the prediction of function via DTI seems promising.
However, for a substantial number of proteins, and subsequently enzymes, their functions are not known, therefore an important challenge in structural genomics is the prediction of function of these uncharacterized proteins [16].
Accurate structural annotation is important for prediction of function and required for in vitro approaches to characterize or validate the gene expression products.
Whilst prediction of function based on sequence homology can be misleading, a study of the domain architecture of RING and RING-like E3 ligases may highlight additional features.
We show that approaches to remedy these problems have other effects on prediction of function which can be understood by how the methods interact with multifunctionality.
Similar(28)
The most reliable prediction-of-function approaches for genomically sequenced protein orfs are obtained using the more computationally intensive HMM modelling and scoring utilities.
The Gene Ontology database (GO, http://www.geneontology.org/), Blast and Interproscan (http://www.ebi.ac.uk/Tools/pfa/iprscan/) were used for prediction of functions of predicted targets.
Using the "guilt by association approach", the identification of SMBDs allowed prediction of functions and mode of regulation for a variety of previously uncharacterized proteins.
Independent of the primary annotation, the prediction of functions of the putative RTX proteins was attempted.
The scale has demonstrated reliability and validity, including prediction of functioning and health care utilization (14).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com