In Fig. 3a, b we show how the performance of prediction changes with changing thresholds.
It was a model with a quavering needle that acted like a whimsical fortune teller whose prediction changed if you shifted from foot to foot ("Today, your fate is to weigh... 110 pounds, no, I mean, 150!").
To investigate this, we ranked instances whose SVM prediction changes drastically depending on whether or not divergence features are used.
PTP1 (P25044) is another protein whose prediction changes from N-signal-free to MTS when divergence is considered.
To do so, we constructed prediction models using patient characteristics and then evaluated whether the prediction changed after adding results from L/S ratio and LBC.
Kanis et al. reported that the sensitivity and specificity of the fracture risk prediction changed with the proportion of the fracture risk group [ 29].
Figure 1 shows that in 55 pairs of tumor and normal tissue, the genomic prediction changed as normal tissue contribution to gene expression increased.
Since in this case the model prediction changes quantitatively, the assumption of S=C might be too much of a simplification?
Instead, we started with a consensus sample of all samples and changed one letter at a time to determine whether the prediction changed toward the positive or the negative side of the classification boundary.
But, Hill added, "it seems like, as the wind blows, my predictions change".
