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Interestingly, several ongoing community-based efforts aim to evaluate the methods used to predict and extract information regarding protein function, such as Biocreative in the field of text mining [ 88, 89], CASP for predicting function and binding sites [ 90], and challenge in function prediction organized by Iddo Friedberg and Predrag Radivojac [ 91].
Parallel cladistic and protein-architecture analyses outlined two plausible criteria for predicting function.
Not only are there many thousands of proteins of unknown function, current approaches for predicting function must be improved upon.
Previous approaches for predicting function which use these data can lead to "circular logic", i.e. using predictions for prediction.
PANTHER is a unique resource that classifies genes and proteins by their functions, using published scientific experimental evidence and evolutionary relationships abstracted by curators with the goal of predicting function even in the absence of direct experimental evidence.
However, they also demonstrate the difficulty of predicting function based on sequence.
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It's different from its previous versions because of two features: widgets and predicting functions; neither of them require knowledge of coding to be used.
We use the network for predicting functions of uncharacterised proteins.
Therefore, predicting functions of lncRNAs remains a greatly substantial challenge.
They may aid in predicting functions for a protein, based on homology.
Thus, predicting functions of proteins should take the relationship between GO terms into consideration.
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