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This "prodrug" phenomenon is highly desirable as it is predicted to substantially reduce potential off-target toxicities of an otherwise highly effective cancer therapeutic.
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For IL-tolerant cellulase cocktails, this includes reducing enzyme loadings by reformulating the cocktails to achieve greater saccharification efficiency; a modification predicted by technoeconomic modeling to substantially reduce overall costs in a biorefinery [ 11].
Growth in the United States will also remain weak next year, the organization predicted, below the level needed to substantially reduce unemployment.
However, UFP in the 20- to 40-nm size range are predicted to have relatively low nasal deposition (Daigle et al. 2003), so oral nasal breathing would not be expected to substantially reduce UFP pulmonary deposition in these studies.
We will pursue a new agreement with Russia to substantially reduce our strategic warheads and launchers.
Mr. Du, the environmental official, dismissed suggestions that Beijing had failed to substantially reduce harmful pollution.
Save some leaves, but you want to substantially reduce the length of the shoots".
Its website states: "In most cases we will be able to substantially reduce your empty rates liability".
"We are not aware of any widespread action by counties to substantially reduce retiree health insurance," he said.
Even before the attacks, networks like NBC had decided to substantially reduce original film operations because of their high costs.
If unlocked, the hydrocarbons have the potential to substantially reduce Europe's reliance on Russia for energy supplies.
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