Subsequently, several other mutations in GUCA1A have been shown to alter amino acids predicted to form or stabilise Ca2+-binding EF-hand motifs in GCAP1, thereby causing a similar loss of Ca2+-sensitivity and constitutive activation of retGC-mediated cGMP production (reviewed in [10]).
(3) A horse-saddle shaped horizontal permeability distribution is predicted across the panel width, where the permeability in strata above the panel's central region is predicted to increase, decrease, and finally stabilise as the face advances.
A horse-saddle shaped horizontal permeability distribution is predicted across the panel width, where the permeability in strata above the panel's central region is predicted to increase, decrease, and finally stabilise as the face advances.
Residues up- and downstream of this loop are predicted to be threaded closely through the neighbouring regions of Domain 1, most probably stabilising the structure.
The axial behaviour is well predicted by the numerical algorithm, and the deflection shows a tendency to stabilise on a plateau, in accordance with the experimental data, but on a slightly over-estimated value.
Molecular dynamics (MD) simulations have also predicted the presence of intermediates in proteins initially characterised as two-state, guiding subsequent protein engineering experiments to stabilise such species so that they can be detected experimentally [46].
With respect to the second mutation, we predict this to be an activating mutation due to its location adjacent to a hydrogen bond known to stabilise the inactive conformation.
The competition needs to stabilise".
They are there to stabilise Afghanistan.
Production eventually falls, helping prices to stabilise.
