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The novel DNA sequence variation g.56167A>G which is predicted to represent a synonymous p.S434S variation was found in this study in a patient with bilateral, progressive, mild to moderate sensorineural hearing loss who is also homozygous for the controversial p.V37I variation in GJB2 [25].
The major anatomic differences in brains of both girls with RTT and Mecp2-deficient mice are reduced dendritic arborization and dendritic spine formation, both of which are indicative of immature neurons and would be predicted to represent a deficit in synaptic formation and/or transmission.
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It should be noted that our proteomics study identified approximately 500 muscle proteins, which is predicted to represent only a fraction of the total muscle proteome.
Patients predicted to represent the CCS3 subtype demonstrated an especially poor prognosis.
It is intriguing that a PPI network predicted to represent 2% of the interactome overlaps with 2% of interactome modeled by the GIL collection.
Factor 2 predicted to represent those interested in gastroenterology, nephrology, & respirology.
Factor 3 predicted to represent those interested in cardiology and critical care.
The wild-type alleles were predicted to represent 94.8% of haplotypes (Fig. 1B).
Factor 1 predicted to represent those interested in general internal medicine.
Factor 4 predicted to represent those interested in non-procedural, lower income subspecialties.
Thus, functional M5-DLO flippases are predicted to represent ∼1% (w/w) of the proteins in TE.
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