Exact(32)
TFAP2A (AP-2) and SP1 are two TFs predicted to regulate the miR-17-92 miR-17-92 miR-17-92ably up-regulated along with the cluster in the first 20 hours post-PMandtimulareonotably
However, the groups of miRNAs predicted to regulate the same mRNA target were found to be co-regulated, indicating that a level of combinatorial control may exist.
miRNAs have been predicted to regulate the expression of more than 600 genes [15], and 225 genes are known targets [16].
miR-107 was predicted to regulate the expression of PDK4 [24], an important component of the cellular response to endurance exercise [2].
They identified 27 highly expressed miRNAs, 15 of which were predicted to regulate the expression of receptors for angiogenic factors [8].
In A. nidulans, these genes encode proteins containing Zn2-Cys6 which are predicted to regulate the genes involved in fatty acid beta-oxidation, transport of acetyl-coA between mitochondria and peroxisomes and the glyoxylate cycle [23].
Similar(28)
These miRNAs have previously been linked to PE and are predicted to regulate members of the TGF-β pathway.
Interactions between miRNAs and their miRNA recognition elements occur via partial complementarity, rendering tremendous redundancy in targeting such that miRNAs are predicted to regulate 60% of the genome, with each miRNA estimated to regulate more than 200 genes.
miRs are predicted to regulate ∼30% of the human genome (Lewis et al, 2005) including genes in stress resistance, fat metabolism, cell proliferation and apoptosis pathways (Ambros, 2003).
From integrated genomic analysis, 8 key miRs (miR-25, miR-29c, miR-101, miR-128, miR-141, miR-182, miR-200a, and miR-506) were predicted to regulate 89% of the miR targets in the network [ 26].
Eight key miRNAs, including miR-506, miR-141, and miR-200a, were predicted to regulate 89% of the targets in this network.
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