Interestingly, the association among BRCA1 mutation carriers was restricted to those carrying mutations proven or predicted to lead to absence of protein expression (Class 1) with no evidence for an association in carriers of BRCA1 mutations likely to generate stable mutant proteins (Class 2) (P-diff = 0.03).
The association was restricted to mutations proven or predicted to lead to absence of protein expression (HR = 0.82, 95% CI: 0.74 to 0.90, P-trend = 3.1 × 10-5, P-difference = 0.03).
HRs are prevalent in Halobacteria; more than 15 strains (Supplementary Table S1) of Halobacteria have been completely sequenced to date, and at least nine of these were proven or predicted to have hop genes.
6 Data whether a particular gene was experimentally proven or predicted to be regulated by a transcription factor was obtained by using the data base CoryneRegNet http://coryneregnet.cebitec.uni-bielefeld.de/v4/.de/v4/
Although originally identified as a positive regulator of virulence gene transcription [ 11], it is now known that BvgAS controls expression of over a hundred different genes whose products are either proven or predicted to participate in a wide variety of cellular activities including many basic physiological functions [ 12- 14].
Looking back at the use of big data in banking, few would have predicted it was possible to prove a correlation between correct use of capitalization when writing your name online and your credit worthiness 20 years ago.
In his 1912 essay Intuitionism and Formalism Brouwer correctly predicted that any attempt to prove the consistency of complete induction on the natural numbers would lead to a vicious circle.
The 26 trusts have incurred the losses despite all hospitals in England sharing most of the £400m of extra funding announced by the health secretary, Jeremy Hunt to help them cope with what many doctors had predicted would prove to be the service's toughest winter.
Formalization and verification using theories(π-calculus, bioambients, κ-calculus and etc). in Computer Science attract attention because it can help prove and predict to a certian degree various kinds of biological processes.
In the context of health information technologies (IT) used in hospital care, such as electronic record systems and telemedicine, 25 years of research and implementation effort has shown that predicted outcomes prove hard to achieve in practice [ 1- 4].
