Exact(1)
We propose, on the basis of a comparison of X-ray crystal structures for wild-type TIM and the L6RM, that ligands bind weakly to the L6RM because a large fraction of the ligand binding energy is utilized to overcome destabilizing electrostatic interactions between the side chains of E168 and E129 that are predicted to develop in the loop-closed enzyme.
Similar(59)
He could be predicted to develop PK in future.
The benefits from improved glycemic control are relatively small due to the fact that complications are predicted to develop late in life, and the benefits of complication reduction are therefore heavily discounted.
At the same time, if we are to respond to the numbers of people who are predicted to develop a form of dementia in the future, we have to improve our understanding of what is happening in people's brains, the treatments we can offer, and find ways in which we can prevent or cure the 100-plus variants of the disease.
We cannot predict whether severe encephalitis was about to develop in these bats.
The total number of people with diabetes is expected to reach 300 million by the year 2025, with the majority of increased cases predicted to be in developing countries.
The prevalence of dementia is predicted to increase rapidly in developing countries.
Finally we will calculate the predicted probability to develop asthma for each child in the validation sample, based on the PIAMA score.
The incidence of NCDs is predicted to increase more rapidly in developing countries than elsewhere in the world [ 14].
Its incidence has been rising steadily over the past few decades, and is predicted to reach epidemic proportions in developing nations.
With another 200m new entrants predicted to join the labour market in developing countries in the next five years, the disparity with adults, and competition for work, is only going to worsen.
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