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It was clunky, hard to read in certain light, very expensive (the same watch costs practically nothing today), and it was predicted to destroy the analog watch industry... who would want a dinosaur on their wrist?
Eight and two tissue-specific A-to-I RNA editing sites were predicted to destroy putative exonic splicing enhancers (ESEs) and exonic splicing silencers (ESSs), respectively.
A search for exonic splicing enhancers revealed that the D153G substitution is predicted to destroy a binding site for the SF2/ASF splicing factor [ 25].
The intron/exon junction variant rs56205617 G>A was predicted to destroy the donor site of the second exon ENSE00003694146 of the isoform ENSP00000379099 by the BDGP splice site predictor programme.
A second allele (Atmin H210Q) was identified through reverse genetic screening of an ENU-mutated DNA archive (Quwailid et al., 2004) (supplementary material Fig. S1A,C); Atmin H210Q contains a histidine to glutamine substitution predicted to destroy function of the fourth ZF, again by interfering with Zn2+ chelation.
In silico analysis predicted that 8 SNPs created a new putative ERE/ARE site while 10 other SNPs were predicted to destroy one or more putative ERE/ARE sites using two different software programs; JASPAR and Cister for the ARE and Cistor and Dragon ERE finder for the ERE.
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The PAZ-domain containing pAgos are predicted to directly destroy virus or plasmid nucleic acids via their nuclease activity, whereas the apparently inactivated, PAZ-lacking pAgos could be structural subunits of protein complexes that contain, as active moieties, the putative nucleases that we predict to be co-expressed with these pAgos.
He said pro-Russian forces had gathered 5,000 fighters in the area and predicted the move to destroy them would last at least a week.
In total, 74,886 SNPs were predicted to affect the coding sequences: 395 SNPs were predicted to cause a premature stop codon, 29 to destroy a termination codon, and 34,257 (45.74 %) to cause non-synonymous substitutions (34,183 missense and 74 SNPs predicted to change at least one base of the first codon of a transcript).
I also predict continued attempts to destroy comprehensive education and undermine teachers in the UK and as you would expect Twitter will represent the anger and disappointment at these policies (and also some support) but, mostly there will be continuity.
Adults over 40 should take the pills only if the predicted exposure is high enough to destroy their thyroid, which may not happen.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com