Sentence examples for predicted to damage the from inspiring English sources
The remaining 4,310 change the make up of the protein that the gene produces and 340 of these are predicted to damage the function of the gene.
We discovered three missense mutations in DMT102, all of which are predicted to damage the protein based on sequence conservation.
Persistent dysregulation of GR subcellular distribution is predicted to damage the hippocampal formation and may underlie many of the effects of PAE on hippocampal-dependent functioning.
The change is predicted to damage the function of the enzyme by both Polyphen and SIFT, and analysis of over-expressed mutant protein in colon cancer cells HCT116 demonstrated decreased CYP24A1 and increased intracellular levels of 1,25(OH)2D3 [ 61].
This variant localised in the putative fourth extracellular domain, and is predicted to be damaging by the SNP prediction programs Polyphen and SIFT (http://tux.embl-heidelberg.de/ramensky/; http://blocks.fhcrc.org/sift/SIFT.html).fhcrc.org/sift/SIFT.html
Based on the PSSM difference and SIFT score, the mutation revealed in COMT gene for individual P7H6 is predicted to be damaging to the protein.
Based on Polyphen2 analysis, a significant proportion of the other mutations in this set of 'druggable' genes are predicted to be damaging to the respective protein function.
The USH2A mutation (Gly713Arg) was, however, intriguing: this variant was predicted to be damaging to the protein, and pathogenic in some populations but not in others (e.g. YRI).
Two prolactin genes (Prl5a2 and Prl4a1) have variants predicted to be damaging in the LH rat.
Both mutations were predicted to be damaging by the CADD algorithm, and one mutation (p.Asp27His) was predicted to be damaging by SIFT algorithm (Ng and Henikoff, 2001; Kircher et al., 2014).
For variations in group [Ch], the proportion of variations predicted to be damaging was high (63/135; 46.7%), and the average allele frequency was relatively low, compared to those predicted to be neutral (Figure S2).
