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To help define which antigens elicit a human antibody response, we have targeted proteins known or predicted to be presented on the surface of the intracellular mature virion (IMV) or the extracellular enveloped virion (EEV).
For instance, nine of the epitopes that were predicted to be presented by the representative of the A2 supertype, HLA-A*0201, induced a response in HLA-A*0201-positive HLA-A*0201-positive HLA-A*0201-positive
In contrast, none of the epitopes that were predicted to be presented by the representative of the B39 supertype, HLA-B*3901, induced a response in B*3901-positive B*3901-positivee simpatientson that none oforhe pathentsimpley HLA-B*3901.
We considered the parts of the HIV-1 genome that putatively is targeted in any of the nine patients, and asked whether the density of nonsynonymous substitutions is higher in the part that is predicted to be presented in a focal patient compared to the part that is not presented.
Similar(56)
Using computational predictive methods, six epitopes were predicted to be present within the VP1 region.
For 29 occluded traits 18 were strongly predicted to be present or absent, and the remaining 11 predictions were neutral.
Along the same line, we used a bioinformatics prediction tool (Cpgplot; EMBOSS); we listed the CpG-rich regions predicted to be present in the vicinity (−1 kb to +1 kb) of the Drosophila IMD-dependent transcription start sites (Fig 5K).
But they still can occur and are as such predicted to be present.
Bacterial microcompartments (BMCs) are protein-bound organelles predicted to be present across 23 bacterial phyla.
The cyclics S12, S18 and S20 were predicted to be present in the largest amounts in agreement with experiment.
Simulations done over the raw quantitative data lead to results presenting phases (major minerals) predicted to be present in water and/or SI of these phases.
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