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Climate change is predicted to alter forests both nationally and globally.
Changing the extracellular [K+] is predicted to alter Vmem according to the Goldman-Hodgkin-Katz equation.
The homeobox genes HOXB3, CDX4 and NOTO exhibit enhanced divergence in giraffe among eutherians and have unique amino acid substitutions predicted to alter protein function.
The CREBBP mutations identified in our HD ALL cases are predicted to alter protein function and primarily affect the HAT domain (89%).
Although the surrounding chromatin in breast myoepithelial primary cells is quiescent, this SNP has also been predicted to alter TF binding motifs.
Two positively selected sites are outside the vaccine epitopes, but are predicted to alter protein conformation.
Most of the variants are predicted to alter protein folding while several other map to functional surface regions.
This SNP is not predicted to alter DNMT1 splicing or protein, and is not evolutionarily conserved beyond primates [52].
We also identified a DOC2A promoter variant in another patient that is predicted to alter transcription factor binding sites for several brain-expressed genes.
One large-effect SNP is predicted to alter the function of the ferulate 5-hydroxylase enzyme (gene: LOC_Os06g24180) and was classified as potentially altering regular intron splicing events.
Of these, 198 were somatic and 45 were predicted to alter gene function based on MutationTaster and Polyphen calculations (Figure 2B, Table S2) [23], [23].
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